Publications

2024

Simonyan K, O'Flynn LC, Hamzehei Sichani A, Fricht SJ, Rumbach AF, Sharma N, Song PC, Worthley A. Efficacy and safety of sodium oxybate in isolated focal laryngeal dystonia: A phase IIb double-blind placebo-controlled cross-over randomized clinical trial. Annals of Neurology. 2024 (in press).

 

Petit J, Ehrlich SK, Tougas G, Bernstein JM, Buie NE, Simonyan K. Impact of Audio-Visual Complexity on Symptomatology of Laryngeal Dystonia: A Virtual Reality Study. Laryngoscope. 2024. Oct 2. Full text.pdf

 

Barbe M, Rusz J, Simonyan K. Responsive deep brain stimulation: A new hope for controlling stimulation-induced dysarthria in essential tremor. Movement Disorders. 2024. Sept 17: 1433-1434. Full text.pdf

 

Laabs BH, Lohmann K, Vollstedt EJ, Reinberger T, Nuxoll LM, Kilic-Berkmen G, Perlmutter JS, Loens S, Cruchaga C, Franke A, Dobricic V, Hinrichs F, Grözinger A, Altenmüller E, Bellows S, Boesch S, Bressman SB, Duque KR, Espay AJ, Ferbert A, Feuerstein JS, Frank S, Gasser T, Haslinger B, Jech R, Kaiser F, Kamm C, Kollewe K, Kühn AA, LeDoux MS, Lohmann E, Mahajan A, Münchau A, Multhaupt-Buell T, Pantelyat A, Pirio Richardson SE, Raymond D, Reich SG, Saunders Pullman R, Schormair B, Sharma N, Sichani AH, Simonyan K, Volkmann J, Wagle Shukla A, Winkelmann J, Wright LJ, Zech M, Zeuner KE, Zittel S, Kasten M, Sun YV, Bäumer T, Brüggemann N, Ozelius LJ, Jinnah HA, Klein C, König IR. Genetic Risk Factors in Isolated Dystonia Escape Genome-Wide Association Studies. Movement Disorders. 2024. Sep 17. Full text.pdf

Kshatriya N, Battistella G, Simonyan K. Structural and functional brain alternations in laryngeal dystonia: A coordinate-based activation likelihood estimation meta-analysis. Human Brain Mapping. 2024. Oct;45(14):e70000. Full text.pdf

 

Dzialas V, Doering E, Eich H, Strafella AP, Vaillancourt DE, Simonyan K, van Eimeren T; International Parkinson Movement Disorders Society‐Neuroimaging Study Group. Houston, We Have AI Problem! Quality Issues with Neuroimaging-Based Artificial Intelligence in Parkinson's Disease: A Systematic Review. Mov Disord. 2024. Sep 5. Full text.pdf

2023
Gail Is Harmata, Ariane E Rhone, Christopher K Kovach, Sukhbinder Kumar, Md Rakibul Mowla, Rup K Sainju, Yasunori Nagahama, Hiroyuki Oya, Brian K Gehlbach, Michael A Ciliberto, Rashmi N Mueller, Hiroto Kawasaki, Kyle Ts Pattinson, Kristina Simonyan, Paul W Davenport , Matthew A Howard III, Mitchell Steinschneider, Aubrey C Chan, George B Richerson, John A Wemmie, Brian J Dlouhy. "Failure to breathe persists without air hunger or alarm following amygdala seizures." JCI Insight 2023. Oct 3:e172423. Full text.pdf

 

Giovanni Battistella and Kristina Simonyan. “Clinical implications of dystonia as a neural network disorder.” Advances in Neurobiology. 2023. 31:223-240. Full text.pdf

 

Stefan K Ehrlich, Giovanni Battistella, and Kristina Simonyan. 2023. “Temporal signature of task-specificity in isolated focal laryngeal dystonia.” Movement Disorders, Jul 25. Full text.pdf

 

Lena C O'Flynn, Steven J Frucht, and Kristina Simonyan. 2023. “Sodium oxybate in alcohol-responsive essential tremor of voice: An open-label phase II study.” Movement Disorders, Jul 14. Full text.pdf

 

Dongren Yao, Lena C O'Flynn, and Kristina Simonyan. 2023. “DystoniaBoTXNet: Novel Neural Network Biomarker of Botulinum Toxin Efficacy in Isolated Dystonia.” Annals of Neurology, Mar;93(3):460-471. Full text.pdf

 

Jana Schill, Kristina Simonyan, Simon Lang, Christian Mathys, Christiane Thiel, and Karsten Witt. 2023. “Parkinson’s Disease Speech Production Network as Determined by Graph-Theoretical Network Analysis.” Network Neuroscience, Jun 30;7(2):712-730. Full text.pdf

 

Saul A Frankford, Lena O Flynn, and Kristina Simonyan. 2023. “Sensory processing in the auditory and olfactory domains is normal in laryngeal dystonia.” Journal of Neurology, Apr;270(4):2184-2190. Full text.pdf

 

Jana Schill, Kristina Simonyan, Maximilian Corsten, Christian Mathys, Christiane Thiel, and Karsten Witt. 2023. “Graph-theoretical insights into the effects of aging on the speech production network.” Cerebral Cortex, Feb 20;33(5):2162-2173. Full text.pdf

2022

Kristina Simonyan, Stefan Ehrlich, Richard Andersen, Jonathan Brumberg, Frank Guenther, Mark Hallett, Matthew A Howard, José R. del Millán, Richard B Reilly, Tanja Schultz, and Davide Valeriani. 2022. “Brain-computer interfaces for treatment of focal dystonia.” Movement Disorders, 37, 9, Pp. 1798-1802. PDF

 

Multimodal collaborative brain-computer interfaces aid human-machine team decision-making in a pandemic scenario

Davide Valeriani, Lena C. O'Flynn, Alexis Worthley, Azadeh Hamzehei Sichani, and Kristina Simonyan. 2022. “Multimodal collaborative brain-computer interfaces aid human-machine team decision-making in a pandemic scenario.” Journal of Neural Engineering, Oct 17;19(5). PDF

 

Short- and long-term cental action of botulinum neurotoxin treatment in laryngeal dystonia

Lena Carolyn O'Flynn and Kristina Simonyan. 2022. “Short- and long-term cental action of botulinum neurotoxin treatment in laryngeal dystonia.” Neurology, 99, 11, Pp. e1178-e119. PDF

 

Voice tremorLaura Lima de Xavier and Kristina Simonyan. 2022. “Voice tremor.” In Tremors. Oxford University Press. PDF

 

Dystonia and Speech Motor Control Laboratory | Department of Otolaryngology-Head & Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School | 243 Charles Street, Suite 421 | Boston, MA 02114 | Simonyan_Lab@MEEI.Harvard.edu | (P) 617-573-6016 | (F) 617-573-6024 |  @SimonyanLab

EES Statement | By embracing diverse skills, perspectives and ideas, we choose to lead. Research and clinical involvement of women, underrepresented minorities, protected veterans, and individuals with disabilities is strongly encouraged.